Novel Biocompatible Hydrogels via Click Chemistry

Currently, the designing and development of advanced hydrogel platforms is one of the important research areas due to their applications in the fabrication of functionalized materials useful in biomedical sciences. The rich literature reveals that most of these advanced materials are derived from the utilization of click reaction-based approaches through arranging the appropriate building blocks together in order to fabricate the desirable hydrogel architectures useful mainly in tissue engineering and drug delivery including the stem cell differentiation. Among the limitations of these materials, the non-degradability of synthetic polymers is responsible for the restricted usage in biomedical fields. Therefore, there is a constant demand to develop systematic methodologies for the synthesis of novel hydrogel materials to improve the degradability of the hydrogels by fine-tuning the functional groups and by incorporating more hydrophilicity for the ready hydrolysis.