Baeyer–Villiger Monooxygenases in Organic Synthesis

The sections in this article are Introduction General Aspects of the Baeyer–Villiger Oxidation Mechanistic Aspects Chemical Versus Enzymatic Baeyer–Villiger Oxidation Biochemistry of Baeyer–Villiger Monooxygenases Catalytic Mechanism Structural Features Application of Baeyer–Villiger Monooxygenases in Organic Chemistry Isolated Enzymes Versus Whole Cells Baeyer–Villiger Monooxygenases Relevant for Synthetic Applications Representative Synthetic Applications Kinetic Resolutions of Racemic Ketones Desymmetrization of Prochiral Ketones Regiodivergent Transformations Large-Scale Application Heteroatom Oxidation Protein Engineering Conclusions and Perspectives Acknowledgments Keywords: Baeyer–Villiger; monooxygenases; enzymes; synthesis; ketones; protein engineering