Induction and Suppression of OTC and Urea Cycle Enzymes in Bacteria, Fungi and Mammals

Human OTC is related phylogenetically to the OTCs of the rat and mouse, less so to that of the frog and distantly to the six fungal OTCs which have been sequenced, called OTCfβs by Labedan(172), The OTCs of E.coli and P.aeruginosa, which like hOTC have had their structure determined by X-ray diffraction, belong to the OTCα group by phylogenetic analysis of their amino acid sequences(172).