A Case of Bilateral Inverted Papilloma with Malignant Transformation on One Side: Analysis of the Expression of Tumor Related Genes on Each Side Tumors

Received March 25, 2013 Revised May 14, 2013 Accepted May 21, 2013 Address for correspondence Ki-Sang Rha, MD Department of OtorhinolaryngologyHead and Neck Surgery, School of Medicine, Chungnam National University, 282 Munhwa-ro, Jung-gu, Daejeon 301-721, Korea Tel +82-42-280-7698 Fax +82-42-253-4059 E-mail ksrha@cnu.ac.kr Inverted papillomas are relatively rare, benign tumors of the sinonasal cavity that generate interest to many clinicians because of their high rate of recurrences, locally invasive character and malignant transformation. The incidence of bilateral occurrence, ranging from 2 to 7%, is extremely rare, and the incidence of synchronous malignancy is also rare too. Here, we report an unusual case of bilateral inverted papilloma with a malignant transformation on one side. We compared the expression of molecules that suggested a relation with malignant transformation in inverted papilloma between each side of the tumors. Korean J Otorhinolaryngol-Head Neck Surg 2013;56:460-4 Key WordsZZInverted papilloma ᆞSquamous cell carcinoma.