HEPSYS-III PROTEOMICS PROFILING OF IN VITRO CELLULAR STEATOSIS MODEL: THE ROLE OF OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION IN THE PROGRESSION OF NAFLD

Reference Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis. Lockman KA, Baren JP, Pemberton CJ, Baghdadi H, Burgess KE, Plevris-Papaioannou N, Lee P, Howie F, Beckett G, Pryde A, Jaap AJ, Hayes PC, Filippi C, Plevris JN. Liver Int. 2012 Mar 19. • Nonalcoholic fatty liver disease (NAFLD) is characterized by intracellular triglyceride accumulation within the liver that potentially, in the presence of inflammation, can progress to steatohepatitis.