The prognostic implications of redox protein expression in stage I-III triple-negative breast cancer.

1035 Background: It is well known that increased reactive oxidative stress (ROS) in cancer cells correlates with poor prognosis and aggressiveness of tumor cells. The aim of this study is to investigate the expression of redox proteins in triple-negative, early breast cancer (TNBC) which shows aggressive phenotype among breast cancer and to demonstrate relationships between expression of ROS markers and clinical outcomes. Methods: Tissues from 135 cases of TNBC from curative surgery at Severance Hospital, Seoul, Korea, from December 2005 to January 2008 were analyzed. Immnunochemical (IHC) staining for redox proteins including thioredoxin reductase, glutathione S-transferase (GST) α, catalase, vitamin D-up-regulated protein 1 (VUDP), and manganese superoxide dismutase (MnSOD) was performed to evaluate the difference between clinicopathological parameters. The mono-carboxylate transporter 4 (MCT4) in stroma was done by IHC staining, too. Results: The median age of 135 TNBC patients was 48 (range 27-76). TN...