Inhibitors of Bacterial Signal Peptidase: A Series of 6-(Substituted oxyethyl)penems.

Aileen E Allsop,Gerald Brooks,Peter D. Edwards,Arun C. Kaura,Robert Southgate

Inhibitors of Bacterial Signal Peptidase: A Series of 6-(Substituted oxyethyl)penems.

1996

Aileen E Allsop
Gerald Brooks
Peter D. Edwards
Arun C. Kaura
Robert Southgate

A series of 6-(substituted oxyethyl)penem esters having the (5S) stereochemistry which are potent inhibitors of Escherichia coli leader peptidase is described. Structure-activity relationships are discussed.

Keywords:

Microbiology
Enzyme
Chemical synthesis
Signal peptidase
Enzyme inhibitor
Antibiotics
Biochemistry
Escherichia coli
Enterobacteriaceae
Bacteria
Biology
antibacterial agent
Stereochemistry

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