Colorimetric Protein Sensing Using Catalytically Amplified Sensor Arrays

The detection of proteins at low concentrations is of critical importance in allergy testing,[1, 2] clinical treatment, [3, 4] and early diagnosis of many diseases, [5, 6] requiring development of fast, sensitive, and cost-effective protein sensors aimed at point-of-care applications. Among these sensors, colorimetric methods provide both enhanced instrumental transduction as well as the potential for direct visual readout. [7] For example, the clearly distinguished color shifts resulting from controllable aggregation of gold nanoparticles have facilitated simple color readout for biosensor applications. [8]