Effect of cyclophosphamide and morin-5’-sulfonic acid sodium salt, alone or in combination, on ADMA/DDAH pathway in rats

Abstract Background The aim of the study was to evaluate the effect of cyclophosphamide (CPX) and morin-5’-sulfonic acid sodium salt (NaMSA) on plasma asymmetric dimethylarginine (ADMA) level and dimethylarginine dimethylaminohydrolase (DDAH) activity in rat liver. Methods The study was performed on Wistar rats receiving normal saline, CPX (15 mg/kg/day), NaMSA (100 mg/kg/day) or both CPX and NaMSA for 10 consecutive days. Results Significant decrease in ADMA level was found in all groups when compared to the control. DDAH activity in the liver was significantly higher in CX group compared to the control group. Conclusion Obtained results of ADMA/DDAH pathway parameters require further research.