The transcription factor ERG recruits CCR4–NOT to control mRNA decay and mitotic progression

Xavier Rambout,Cécile Detiffe,Jonathan Bruyr,Emeline Mariavelle,Majid Cherkaoui,Sylvain Brohée,Pauline Demoitié,Marielle Lebrun,Romuald Soin,Bart Lesage,Katia Guedri,Monique Beullens,Mathieu Bollen,Thalia A. Farazi,Richard Kettmann,Ingrid Struman,David E. Hill,Marc Vidal,Véronique Kruys,Nicolas Simonis,Jean-Claude Twizere,Franck Dequiedt

The transcription factor ERG recruits CCR4–NOT to control mRNA decay and mitotic progression

2016

The canonical transcription factor ERG promotes degradation of a subset of mRNAs linked to mitotic progression by recruiting the CCR4–NOT deadenylation complex, thus revealing a new regulatory interplay between mRNA synthesis and degradation.

Keywords:

Transcription factor
MRNA Decay
RNA
CCR4
MRNA synthesis
Molecular biology
Mitosis
Erg
Transcription (biology)
Biology
mitotic progression
ccr4 not

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