Copper(II)-Catalyzed Enantioselective Fluorination of β-Keto Esters Using Chiral Spiro Oxazoline Ligands

Highly enantioselective fluorination of α-alkyl-β-keto esters was performed using a chiral Lewis acid catalyst prepared from Cu(OTf) 2 and chiral spiro oxazoline ligands. The fluorination proceeded in a highly enantioselective manner both when cyclic and acyclic substrates were applied to the reaction. Fluorination of α-alkyl­malonates was also performed to afford the corresponding products in good enantioselectivity.