수영운동의 중단과 재개 시 뇌의 신경전달물질, 신경성장인자 및 신경세포생성에 미치는 영향

The aim of the present study was to investigate the effects of swimming training, detraining and retraining on neurotransmitter(5-HT, TPH), neurotrophin(BDNF) and neurogenesis(BrdU), and relationship with μ-opioid receptor in the mice brain. Male Crl:CD-1 (ICR) mice were divided into control group(C; n = 10), swimming training group(ST; n = 10), detraining group(DT; n = 10) and retraining group(RT; n = 10) at the age of 6 weeks. The mice in swimming training group was made to swim(5 days/week, 60 min/day) for 12 weeks. Detraining group was made to swim for 4 weeks and remained sedentary for the next 8 weeks. Retraining group was made swim for 4 weeks, remained sedentary for the next 4 weeks, and swim for the last 4 weeks. In the present results, swimming training enhanced neurotransmitter, neurotrophin expression and hippocampal neurogenesis. Detraining significant decreased and retraining showed similar level compared to the control group. μ-opioid receptor in the swimming training group showed significant decreased compared to the control group. But detraining group showed more significant increased. There is a close connection between detraining and μ-opioid receptor. Here in this study, swimming training improves brain functions, but sudden cessation of swimming training might bring decline of the brain functions.