Hematological and serum biochemical evaluation of imatinib mesylate induced toxicity in wistar rats and its amelioration with grape seed proanthocyanidins

Non-target organ toxicities has been a critical issue in the clinical management of various neoplasm through chemotherapeutic agents. Imatinib mesylate, the first molecule among Tyrosine kinase inhibitor class of drugs has also been associated with hematological and various organ toxicities among human and animal patients. Grape seed proanthocyanidins on other hand was attributed with the protective abilities against various drug induced organ toxicities. The present study was conducted to investigate the ameliorative efficacy of GSPs in imatinib induced toxicity, through evaluation of hematological and serum biochemical parameters in male Wistar rats. The results indicated statistically significant (P<0.05) decrease in hematological values (TEC, Hb conc., PCV and TLC) and significant increase (P<0.05) in serum biochemical values (AST, ALT, ALP, Total protein, Creatinine and LDH) among drug control animals compared to normal ones. GSPs mediated amelioration was evident with significantly improved hematological and serum biochemical values among the animals co-administered with both imatinib and GSP extract, suggesting the chemoprotective efficiency of GSPs against imatinib mesylate induced non-target toxicity.