DESENVOLVIMENTO, CARACTERIZAÇÃO E AVALIAÇÃO DA CITOTOXICIDADE DE NARINGINA E NARINGENINA NANOENCAPSULADAS 1 DEVELOPMENT, CHARACTERISATION AND EVALUATION OF CYTOTOXITITY OF NANOCAPSULED NARINGIN AND NARINGENIN

The reactive species (ERs) and the oxidative stress contribute to the pathophysiology of several diseases. An innovative alternative for the protection of organs such as the brain is the use of flavonoids with antioxidant activity such as naringin and naringenin. However, these two compounds exhibit low bioavailability when administered orally. An alternative to overcome this limitation is to use nanocarriers, such as nanocapsules (NC), which allow the increase of the bioavailability and efficacy of the active ingredient. Therefore, the present study evaluated the release profile of drugs from suspensions in vitro as well as certain effects of nanocoated drugs on cell viability in Vero cell line. The NCS naringin and naringenin showed acidic pH, particle diameter