Influence of Process Conditions on the Crystallization and Transition of Metastable Mannitol Forms in Protein Formulations During Lyophilization

Wenjin Cao,Yong Xie,Sampathkumar Krishnan,Hong Lin,Margaret Speed Ricci

Influence of Process Conditions on the Crystallization and Transition of Metastable Mannitol Forms in Protein Formulations During Lyophilization

2013

Wenjin Cao
Yong Xie
Sampathkumar Krishnan
Hong Lin
Margaret Speed Ricci

Purpose To study the impact of different process conditions and formulation compositions on metastable mannitol forms in protein formulations during lyophilization.

Keywords:

Crystallization
Mannitol
Metastability
Chromatography
Biochemistry
Chemistry
raman imaging
process conditions
Raman spectroscopy
pharmacology toxicology

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