A New Approach to the Stereoselective Synthesis of Conveniently Protected α-Allyl Substituted Amino Acids; Chiral Key Compounds in the Synthesis of Constrained Peptide Isostere Constituents.

Abstract Enantiomerically pure α-allyl-N-Boc-aminoamides were prepared by Curtius rearrangement of α,α-dialkyl chiral 2-cyanoesters obtained by the diastereoselective allylation of chiral 2-cyanoesters according to a modification of our previously described procedure.