Evaluation of the Relationship Between Luteinizing Hormone Levels and Body Mass Index in Girls With Idiopathic Central Precocius Puberty

Objective: Excess  adiposity  has  effects on various aspects of pubertal development as  the timing  of pubertal initiation and  hormonal parameters during  puberty. We aimed to determine the effect of BMI on peak LH (luteinizing  hormone) levels obtained by standard GnRH (Gonadotropin  Releasing  Hormone) stimulation  test in girls with central precicous puberty. Materials and Methods:  A total of 59  female patients who were diagnosed as idiopathic  central precicous pubertywere included in the study. Anthropometric measurements at the time  of  GnRH stimulation test and basal/stimulated gonadotropin levels were evaluated. The relationship between BMI and gonadotropins  was investigated. Results:  The  mean age  of the  participants  was 7.11±1.01 (3.20-7.94) years. 21 cases(35 %) were overweight/obese. 67.8% (n = 40) of the cases were presented with breast development and 64.4% (n = 38) were in stage 2, 35.6% (n = 21) were in stage 3 puberty. There was no  significant correlation between BMI SDS and basal/peak LH levels (p=0.531, p= 0.598 for stage  2  and  p=0.126, p=0.827  for stage  3  puberty respectively), peak LH / FSH (follicle-stimulating hormone) ratio (p=0.408 for  stage  2  and  p=0.797  for stage  3  puberty) in patients according  to  both puberty stages. There was not  also any correlation  between BMI /BMI SDS  and peak LH in total study  group.Basal  LH, FSH, E2  and  peak LH levels  did not  vary  among normal weight, overweight  and  obese  cases. Conclusion: Body mass index had no effect on basal and stimulated gonadotropin levels in girls with central precicous puberty in  different stages of puberty.