Hepatitis B reactivation and timing for prophylaxis

It is known that immunotherapy and cancer chemotherapy may cause hepatitis B virus(HBV)reactivation in hepatitis B surface antigen carriers and inactive chronic hepatitis B patients.Guidelines recommend antiviral prophylaxis regardless of HBV DNA levels to prevent reactivation.We read from the article written by Liu et al that Lamivudine was given inadequate time for antiviral prophylaxis.