Influence of histologic types and subtypes on survival outcomes of intermediate-high and high-risk renal cell carcinoma following nephrectomy: Findings from the SEER database

Abstract Objective To understand the influence of histologic subtypes on the survival outcomes of intermediate-high and high-risk renal cell carcinoma (RCC) following nephrectomy Methods This study employed data files from the SEER Program to identify patients diagnosed with intermediate-high or high risk RCC and treated with nephrectomy. Unadjusted Kaplan Meier curves, and multivariable Cox regression analyses were applied to estimate the hazards of histologic types for overall survival (OS) and cancer-specific survival (CSS). Results OS was higher for chromophobe (HR=0.58, 95% CI 0.47-0.70; p