The combined detection of autoantibody characteristics in systemic lupus erythematosus.

Objective: To investigate the combined detection of the autoantibody characteristics in systemic lupus erythematosus (SLE). Methods: 105 SLE patients admitted to our hospital from May 2019 to September 2020 were placed in the SLE examination group (the SE group), 110 patients with rheumatic diseases admitted to our hospital during the same period were placed in the disease control group (the DC group), and 100 healthy people who came to our hospital for physical examinations during the same time period were placed in the healthy control group (the HC group). The SLE patients’ clinical data were recorded. The patients’ antinuclear antibody (ANA), anti-dsDNA, anti-SM, anti-SSA, and anti-rRnp levels were measured. Results: There were no significant differences in the occurrences of fever, alopecia, photosensitivity, interstitial lung disease, Raynaud’s phenomenon, pulmonary arterial hypertension, or osteoporosis. (P > 0.05), but there were higher incidences of arthralgia and butterfly erythema in the female patients (P 0.05). The sensitivities of the combined measurements were higher than the single autoantibody measurements (P < 0.05). Conclusion: Single autoantibody detection has the disadvantage of low sensitivity or specificity. The combined detection of autoantibodies can effectively improve the sensitivity and specificity of SLE detection, so it is worthy of clinical promotion.