Karcinom pankreatu a faktory životního stylu

Backgrounds: Pancreatic cancer is a serious cancer with unfavorable prognosis. Due to the differences in the incidence of pancreatic cancer in different regions, it is clear that factors associated with lifestyle play an important role in the etiology. The aim of this study was to evaluate the impact of selected lifestyle factors in relation to pancreatic cancer. Materials and Methods: The study included a total of 529 subjects, including 309 cases and 220 control subjects. Cases were selected in hospitals in three centers (University Hospital Olomouc, University Hospital Ostrava, Hospital Ceske Budejovice) of subjects who were newly diagnosed with pancreatic cancer and who lived in the region. The control group was obtained in cooperation with selected general practitioners for adults, and is a population control group. Results: Analyses compared  persons who reported consuming alcohol with those who do not consume alcohol. Results showed a statistically significant inverse association, even after adjustment for the other studied factors (OR = 0.57, 95% CI 0.36 to 0.89). When assessing leisure time physical activity, results showed statistically significant inverse association and 35% decrease in the risk (crude OR = 0.65, 95% CI 0.45 to 0.93), and this inverse association was confirmed after adjustment for other studied factors although the result is on the border of statistical significance (adjusted OR = 0.68, 95% CI 0.44 to 1.04). Drinking coffee and tea has only a marginal impact on the occurrence of pancreatic cancer, although the medium and high consumption of black tea was found increased risk by 90 or 44% respectively. Smoking is considered a causal risk factor for pancreatic cancer, but in this study a positive association was not found. The study found no statistically significant association the relationship between overweight and obesity. Conclusion: Physical activity, dietary measures that will lead to weight loss and education to non-smoking can have a significant impact on the primary prevention of cancer.