Aqueous extract of Bowdichia virgilioides stem bark inhibition of allergic inflammation in mice
2016
This study evaluated the anti-allergenic properties of the aqueous extract of the stem bark from
Bowdichia virgilioides (AEBv). Oral administration of AEBv inhibited the plasma protein leakage at 30
min post allergenic challenge in Swiss mice actively sensitized with ovalbumin (OVA). AEBv inhibited
OVA-induced histamine release in vitro in tissues obtained from sensitized mice. AEBv-treated
mice exhibited a lower influx of neutrophils and eosinophils in allergen-induced pleurisy 24 h post
OVA-challenge. This treatment also reduced tumor necrosis factor (TNF)-α content in the pleural
effluent. Furthermore, AEBv treatment drastically inhibited the high levels of interleukin (IL)-5 and
CC chemokine eotaxin (CCL11) mRNA expression in pleural leukocytes after OVA-challenge.
Preliminary toxic effects were assessed, and a qualitative phytochemical profile was performed.
The extract contained condensate tannins, flavonoids, saponins, and steroids but not triterpenes
and alkaloids. Oral treatment with AEBv did not induce signs of systemic toxicity or genotoxic
effects. These results demonstrated that AEBv is a potent inhibitor of contributors to the allergic
inflammatory response, supporting its use in folk medicine to treat allergic conditions.
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