Acryloyl distamycin derivatives substituted associated manufacturing process and its use as antitumor and antiviral agents.

The present invention relates to derivatives of acryloyl distamycin represented by formula (I), wherein: n is 2, 3 or 4; R1 and R2 are selected, each independently from hydrogen, halogen and (C 1-4); R.sup.3 is hydrogen or halogen; B is selected from (1), (2), (3), (4), (5), (6) and (7); Wherein R4, R5, R6, R7 YR 8 are each independently hydrogen or (C 1-4), with the proviso that at least one of R 4, R 5 YR 6 BE A RENT ( C 1-4) AND THE SALES OF SUCH pharmaceutically acceptable derivatives. Such compounds are useful as antitumor agents and antivirals.