Abstract 15751: Pharmacodynamic Effect of ARO-ANG3, an Investigational RNA Interference Targeting Hepatic Angiopoietin-like Protein 3, in Patients With Hypercholesterolemia

Gerald F. Watts,Christian Schwabe,Russell S. Scott,Patrick Gladding,David R. Sullivan,John M. Baker,Peter M. Clifton,James D. Hamilton,Bruce D. Given,Javier San Martín,Stacey Melquist,Ting Chang,N Rajicic,Ira J. Goldberg,Daniel Gaudet,Joshua W. Knowles,Robert A. Hegele,Christie M. Ballantyne

Abstract 15751: Pharmacodynamic Effect of ARO-ANG3, an Investigational RNA Interference Targeting Hepatic Angiopoietin-like Protein 3, in Patients With Hypercholesterolemia

2020

Gerald F. Watts
Christian Schwabe
Russell S. Scott
Patrick Gladding
David R. Sullivan
John M. Baker
Peter M. Clifton
James D. Hamilton
Bruce D. Given
Javier San Martín
Stacey Melquist
Ting Chang
N Rajicic
Ira J. Goldberg
Daniel Gaudet
Joshua W. Knowles
Robert A. Hegele
Christie M. Ballantyne

Background: Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride (TG) and lipoprotein (LP) metabolism by inhibiting liver and endothelial LP lipases and reduces plasma LDL-C. In Phase 1 Stu...

Keywords:

Medicine
Lipoprotein
Pharmacodynamics
ANGPTL3
Angiopoietin-like Protein
RNA interference
Hyperlipidemia
Pharmacology
Metabolism
Triglyceride

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