RHO KINASE ACTIVITY, CONNEXIN40 AND ATRIAL FIBRILLATION: MECHANISTIC INSIGHTS FROM END STAGE RENAL DISEASE UNDER DIALYSIS PATIENTS

Objective:Evidence on cellular and molecular mechanisms that lead to atrial fibrillation (AF) are scanty. Increased expression of ROCK and myosin phosphatase target subunit 1 (MYPT-1), involved in ROCK signaling were shown in left atrial appendage biopsies of AF patients, which correlated with the e