Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord.
2005
Neuronal migration and lamina-specific primary afferent projections are
crucial for establishing spinal cord circuits, but the underlying mechanisms
are poorly understood. Here, we report that in mice lacking Dcc
(deleted in colorectal cancer), some early-born neurons could not migrate
ventrally in the spinal cord. Conversely, forced expression of Dcc
caused ventral migration and prevented dorsolateral migration of late-born
spinal neurons. In the superficial layer of the spinal cord of
Dcc –/– mutants, mislocalized neurons are
followed by proprioceptive afferents, while their presence repels nociceptive
afferents through Sema3a. Thus, our study has shown that Dcc
is a key molecule required for ventral migration of early-born neurons, and
that appropriate neuronal migration is a prerequisite for, and coupled to,
normal projections of primary afferents in the developing spinal cord.
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