Proton-Pump Inhibitors Therapy and Blood Pressure Control

Objective: To evaluate the potential impact of inhibitors of proton-pump in blood-pressure. .Methods: In a 24-hour-ambulatory-blood-pressure-monitoring (AMBP)-database we analyzed records of 462-hypertensive-patients according Proton-Pump Inhibitors (PPI). 150(33%)-patients were regularly users of PPI, and 312(67%) nonusers of PPI. Ambulatory-blood-pressure was measured non-invasively for 24--hours by the Spacelab-devices programmed-to-measure every 20-minutes during-daytime and every 60-minutes during-nighttime.Results: Systolic-blood-pressure(SBP) was lower in the Proton-Pump-Inhibitors (PPI)-group (13520.vs.13916mmHg, p=0,02) as well as diastolic-blood-pressure (DBP) (7610.vs.8310mmHg, p<0.001). Multivariate-analysis showed that use of beta-blocker(OR, 2.60) and PPI(OR, 2.70), were independently associated with blood-pressure-control.Conclusions: This study shows that concomitant PPI therapy in hypertensive-patients was associated with a small but statistically significant-reduction in 24-hours-BP, even after multivariate-adjustment. However, This statistical difference seems to lack clinical relevance.