Anti-Ulcerogenic Evaluation of the Persian Tooth Brush Tree (Salvadora Persica)

The effect of the lyophilized decoction of Salvadora persica on ulceration induced by ethanol, indomethacin and cold restraint stress was investigated in rats. Pre-treatment tests in rats revealed that the extract possessed significant protective action against ulcers induced by ethanol or stress. The protective effect was not altered by indomethacin, administered as a prostaglandin biosynthesis inhibitor. Salvadora persica shows some increase in gastric mucus with a certain diminution in the ulcer index in cold stress-induced ulcers. However, the drug failed to heal ethanol and indomethacin-induced ulcers.