Recognition at chiral interfaces: From molecules to cells

Abstract As a ubiquitous phenomenon in nature, chirality plays a pivotal role in a variety of biological and physiological processes. The construction of chiral interfaces and exploration of their effect on the behavior of various substances, especially biomolecules such as DNA, proteins and cells, are effective ways to fully understand the chirality in nature and to further develop their applications. In order to accelerate the research process of chiral mechanism and provide new ideas for the interpretation of chiral phenomena in nature, thus further promoting the applications of chiral effect in biology, medicine and other related fields, various types of chiral interfaces were prepared and their effects on drug molecules, biomolecules and cells have also been investigated. This review covers the preparation of various chiral interfaces with different geometrical structures and the stereoselective interaction between biological or related systems and the chiral interface materials. Moreover, some challenges and perspectives are also presented.