Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization.

Provided herein are methods of inhibiting neovascularization of malignant tissue in a subject by contacting or administering an alpha-emitting radioconjugate, such as a radioimmunoconjugate, for example, an antibody, targeting the vascular endothelium. Also provided are methods of treating a cancer, such as a prostate cancer, in a subject by administering the alpha-emitting radioimmunoconjugate. Alternatively, a prostate cancer may be treated by the sequential administration of an 225Ac-immunoconjugate and a chemotherapeutic agent.