A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

Simon N. Stacey,Patrick Sulem,Aslaug Jonasdottir,Gisli Masson,Julius Gudmundsson,Daniel F. Gudbjartsson,Olafur Th. Magnusson,Sigurjon A. Gudjonsson,Bardur Sigurgeirsson,Kristin Thorisdottir,Rafn Ragnarsson,Kristrun R. Benediktsdottir,Bjørn A. Nexø,Anne Tjønneland,Kim Overvad,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Kari Hemminki,Cristina Corredera,Victoria Fuentelsaz,Pilar Grasa,Sebastian Navarrete,Fernando Fuertes,María Dolores García-Prats,Enrique Sanambrosio,Angeles Panadero,Ana de Juan,Almudena García,Fernando Rivera,D Planelles,Virtudes Soriano,Celia Requena,Katja K. Aben,Michelle M. van Rossum,Ruben G. Cremers,Inge M. van Oort,Dick Johan van Spronsen,Jack A. Schalken,Wilbert H.M. Peters,Brian T. Helfand,Jenny Donovan,Freddie C. Hamdy,Daniel Badescu,Ovidiu Codreanu,Mariana Jinga,Irma Eva Csiki,Vali Constantinescu,Paula Badea,Ioan Nicolae Mates,Daniela E. Dinu,Adrian Constantin,Dana Mates,Sjöfn Kristjánsdóttir,Bjarni A. Agnarsson,Eirikur Jonsson,Rosa B. Barkardottir,Gudmundur V. Einarsson,Fridbjorn Sigurdsson,Páll Helgi Möller,Tryggvi Stefansson,Trausti Valdimarsson,Oskar Johannsson,Helgi Sigurđsson,Thorvaldur Jonsson,Jon G. Jonasson,Laufey Tryggvadottir,Terri Rice,Helen M. Hansen,Yuanyuan Xiao,Daniel H Lachance,Brian Patrick O’Neill,Matthew L. Kosel,Paul A. Decker,Gudmar Thorleifsson,Hrefna Johannsdottir,Hafdis T. Helgadottir,Asgeir Sigurdsson,Valgerdur Steinthorsdottir,Annika Lindblom,Robert S. Sandler,Temitope O. Keku,Karina Banasik,Torben Jørgensen,Daniel R. Witte,Torben Hansen,Oluf Pedersen,V. Jinga,David E. Neal,William J. Catalona,Margaret Wrensch,John K. Wiencke,Robert Brian Jenkins,Eduardo Nagore,Ulla Vogel,Lambertus A. Kiemeney,Rajiv Kumar,J. I. Mayordomo,Jón Ólafsson,Augustine Kong,Unnur Thorsteinsdottir,Thorunn Rafnar,Kari Stefansson

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

2011

Simon N. Stacey
Patrick Sulem
Aslaug Jonasdottir
Gisli Masson
Julius Gudmundsson
Daniel F. Gudbjartsson
Olafur Th. Magnusson
Sigurjon A. Gudjonsson
Bardur Sigurgeirsson
Kristin Thorisdottir
Rafn Ragnarsson
Kristrun R. Benediktsdottir
Bjørn A. Nexø
Anne Tjønneland
Kim Overvad
Peter Rudnai
Eugene Gurzau
Kvetoslava Koppova
Kari Hemminki
Cristina Corredera
Victoria Fuentelsaz
Pilar Grasa
Sebastian Navarrete
Fernando Fuertes
María Dolores García-Prats
Enrique Sanambrosio
Angeles Panadero
Ana de Juan
Almudena García
Fernando Rivera
D Planelles
Virtudes Soriano
Celia Requena
Katja K. Aben
Michelle M. van Rossum
Ruben G. Cremers
Inge M. van Oort
Dick Johan van Spronsen
Jack A. Schalken
Wilbert H.M. Peters
Brian T. Helfand
Jenny Donovan
Freddie C. Hamdy
Daniel Badescu
Ovidiu Codreanu
Mariana Jinga
Irma Eva Csiki
Vali Constantinescu
Paula Badea
Ioan Nicolae Mates
Daniela E. Dinu
Adrian Constantin
Dana Mates
Sjöfn Kristjánsdóttir
Bjarni A. Agnarsson
Eirikur Jonsson
Rosa B. Barkardottir
Gudmundur V. Einarsson
Fridbjorn Sigurdsson
Páll Helgi Möller
Tryggvi Stefansson
Trausti Valdimarsson
Oskar Johannsson
Helgi Sigurđsson
Thorvaldur Jonsson
Jon G. Jonasson
Laufey Tryggvadottir
Terri Rice
Helen M. Hansen
Yuanyuan Xiao
Daniel H Lachance
Brian Patrick O’Neill
Matthew L. Kosel
Paul A. Decker
Gudmar Thorleifsson
Hrefna Johannsdottir
Hafdis T. Helgadottir
Asgeir Sigurdsson
Valgerdur Steinthorsdottir
Annika Lindblom
Robert S. Sandler
Temitope O. Keku
Karina Banasik
Torben Jørgensen
Daniel R. Witte
Torben Hansen
Oluf Pedersen
V. Jinga
David E. Neal
William J. Catalona
Margaret Wrensch
John K. Wiencke
Robert Brian Jenkins
Eduardo Nagore
Ulla Vogel
Lambertus A. Kiemeney
Rajiv Kumar
J. I. Mayordomo
Jón Ólafsson
Augustine Kong
Unnur Thorsteinsdottir
Thorunn Rafnar
Kari Stefansson

To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide association study of 16 million SNPs identified through whole-genome sequencing of 457 Icelanders. We im ...

Keywords:

Genetics
Germline
Cancer
Germline mutation
Single-nucleotide polymorphism
Genome-wide association study
Basal cell carcinoma
Li–Fraumeni syndrome
Biology
Whole genome sequencing
Polyadenylation
cancer susceptibility

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