Treatment of Wilms Tumor: A Report from the Turkish Pediatric Oncology Group (TPOG)
2010
Aim To standardize diagnosis and treatment of childhood Wilms tumor (WT) in Turkey. Methods & Patients Between 1998 and 2006, WT patients were registered from 19 centers. Patients Results 165/254 registered cases were eligible (bilateral, 5.9%) [median age 3.0 years; M/F:0.99; 50/165 cases £2 years]. 9.7% cases had UH tumors. Disease stages were: stage I 23.6%; IIA 36.4%; IIB 5.5%; III 22.4%; IV 12.1%. Cases >2 years had significantly more advanced disease. 1/11 cases with recurrent disease died; 2/165 had progressive disease, 2/165 had secondary cancers and all four died. In all cases four-year OS and EFS were 92.8% and 86.5%, respectively. Both OS and EFS were significantly worse in stage IV. Conclusions Despite problems in patient management and follow-up, treatment results were encouraging in this first national experience with a multicentric study in pediatric oncology. Revisions and modifications are planned to further improve results and minimize short and long term side effects.
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