Prevention and treatment of bone loss induced by inflammation and / or immunologically mediated.

Use of an inhibitor of 11-a-HSD type 1 and type 2 or a pharmaceutically acceptable salt thereof, for the preparation of a pharmaceutical agent for the prevention and / or treatment of bone loss and / or cartilage induced inflammation and / or immune-mediated, wherein said use is for the prevention and / or treatment of lytic bone metastases, arthritis, juvenile chronic arthritis and / or adjuvant arthritis, infectious diseases, bone loss by HIV, tooth loss, inflammation bone marrow and / or synovial inflammation.