Resistance of intestinal strains of Bacteroides to antibiotics and chemotherapeutic agents

: Antibacterial therapy of anaerobic infections usually involves chemotherapy. The basis of therapy is assessment of the minimal inhibitory concentration (MIC) of antibiotic or chemotherapeutic agents needed to eliminate the suspected causal agents of infection. The authors assessed MIC of 9 selected antibiotics and chemotherapeutic agents (metronidazole, chloramphenicol, clindamycin, azlocillin, mezlocillin, cephoxitin, oxytetracycline, lincomycin, erythromycin) by the dilution method in blood agar in 157 strains of the most important types of the genus Bacteroides which were isolated in 1985-1989 from different clinical materials in Bratislava and in Halle (GDR). All tested strains were sensitive to metronidazole and chloramphenicol. Resistance to clindamycin was very rare. Strains resistant to azlocillin, mezlocillin and cephotoxin were more frequent. A high resistance to lincomycin, oxytetracycline and erythromycin was found. Difference in sensitivity of strains from the CSSR and GDR were slight. Similarly results of the present work differed little from those of previous work.