Pediatric recurrent Rosai-Dorfman disease with germline heterozygous SLC29A3 and somatic MAP2K1 mutations.

Pediatric Recurrent Rosai-Dorfman Disease with germline heterozygous SLC29A3 and somatic MAP2K1 mutationsShruthi Suryaprakash, MD1, Amy George, RN2, Scott Langenburg, MD3, and Sureyya Savasan, MD2,41Department of Pediatrics, Children’s hospital of Michigan, Detroit2Division of Hematology/Oncology, Children’s hospital of Michigan, Detroit3Division of Pediatric Surgery, Children’s hospital of Michigan, Detroit4Division of Hematology/Oncology and Blood and Marrow Transplant Program, Department of Pediatrics, Children’s Hospital of Michigan, Barbara Ann Karmanos Cancer Center, Central Michigan University College of Medicine, DetroitCorrespondence: Sureyya Savasan, MD3901 Beaubien Blvd.Division of Hematology/OncologyBlood and Marrow Transplant ProgramChildren’s Hospital of MichiganDetroit, Michigan 48201E-mail: savas1s@cmich.eduPhone: 313-745-5516 Fax: 313-745-5237Text word count: 500Reference count: 16Tables and figures: 1Page number: 7Short running title: Germline and somatic mutations in recurrent Rosai-Dorfman diseaseKey words: recurrent RDD, germline SLC29A3 mutation, somatic MAP2K1 mutation, dysgammaglobulinemia, clonal T-LGL proliferation