Pharmacokinetics of Gentamicin in Renally-Impaired Goats Following Intravenous Administration

Abstract Ahmad, A.H. and Sharma, L.D. 2001. Pharmacokinetics of gentamicin in renally-impaired goats following intravenous administration. J. Appl. Anim. Res., 20:213–220. The pharmacokinetics of gentamicin was studied in goats given a single intravenous dose (5 mg/kg) of uranyl nitrate for renal impairment. Gentamicin was injected intravenously (5 mg/kg) on the 7th day after injection of uranyl nitrate, when the serum creatinine and blood urea nitrogen concentrations rose significantly. An elimitiatiOn half-life (t1/2β) of 425 min. was observed. The plasma clearance (CI) in renally-impaired goats was 0.3 ml/min. kg. Hie volume of distribution was 187 ml/kg. The area under the curve was 16625 ug.min/ml. A dose of 2.5 mg/kg every 24 h was calculated in renally impaired goats based on the pharmacokinetic parameters in present study.