Abstract 17104: Smooth Muscle Protein 22 alpha Promoter-driven Insulin-like Growth Factor I (IGF-1) Receptor Deficiency Increases Atherosclerosis and Promotes Atherosclerotic Plaque Destabilization

We have previously shown that IGF-1 reduces atherosclerosis in Apoe-null mice. We have now generated Apoe-null mice with SM22a promoter-driven IGF-1 receptor (IGF-1R) deficiency (22KI mice). IGF-1R was decreased in both adventitia-free aortas (>80% decrease, P 80...