Avian influenza vaccines

: The review gives data on the designing of avian influenza vaccines and the preparation of human safe vaccine strains from the highly virulent strains of these viruses. It considers activated and live vaccines, promising adjuvants for vaccines, as well as recombinant, virus-vector, and DNA vaccines and virus-like particles. The results of a number of clinical trials of avian influenza vaccines are examined. Analysis of the data published leads to the conclusion that cell culture-based whole-virion vaccines with adjuvants are promising in combating avian influenza.