The Role of M6A Modification in the Regulation of Tumor Related lncRNAs

Abstract N6-methyladenosine (m6A) is the most abundant modification in eukaryotic cells, and it regulates RNA transcription, processing, splicing, degradation, and translation. Long non-coding RNAs (lncRNAs), as transcriptional products with no or limited protein coding ability over 200 nucleotides in length, play an important role in epigenetic modification, mRNA transcription, splicing, stability, translation and other biological functions. Extensive studies show that both m6A modification and lncRNAs are involved in the pathogenesis of various diseases, such as kinds of cancers, heart failure, Alzheimer’s disease, periodontitis, human abdominal aortic aneurysm, obesity. To date, m6A modification has been identified as an important biological function in enrichment and regulation of lncRNAs. In this review, we summarize the role of m6A modification in the regulation and function of tumor related lncRNAs. Moreover, we discuss the potential applications and possible future directions in the field.