Effect of Gyrus Folding Angle on Peak Electric Field in Cerebral Cortex

Reported transcranial current stimulation (tCS) effects on cerebral activity leave numerous questions open regarding the involved mechanisms of action. A number of studies have identified clear physiological effects, however it remains to be understood how to take into account interindividual variability to tCS: For example, to what extent does individual brain geometry, such as cerebral tissues morphology, impact this prediction? Here, we aimed at evaluating how the geometry of cortical tissue surfaces impacts the charge distribution and therefore the electric fields induced by tCS.