[Specific features of pulmonary tuberculosis course in patients with insulin-dependent diabetes mellitus in relation to a varying HLA phenotype].

: The examination and treatment of 67 new cases of infiltrative pulmonary tuberculous developed in the presence of insulin-dependent diabetes revealed two different types of the course of a tuberculous process. Due to therapy there was nearly complete resolution of inflammatory changes in 36 (54%) patients (Group 1). Large caseous foci of the tuberculoma type were formed in 31 (46%) patients (Group 2), including in 19 on admission and in 12 during chemotherapy Group 1 more frequently showed antigens of HLA A1 (p < 0.02) and DR2 (p < 0.01). Antigens of HLA B15 and DR6 were encountered only in this group. Those of HLA A2 (p < 0.01), DR3 (p < 0.01) were more commonly detected in Group 2. The HLA phenotype may be assumed to be an important factor that influences the course of pulmonary tuberculosis in patients with insulin-dependent mellitus and it may be of prognostic value.