ortho-Directed Lithiation of (2-Methoxy) ethoxy- and (2-Dimethylamino) ethoxy-arenes

ortho-Directed lithiation of a number of (2-methoxy) ethoxy- and (2-dimethylamino) ethoxyarenes has been investigated. Lithiation of these compounds followed by treatment with various electrophiles afforded ortho-substituted products in moderate to excellent yields.