Steroid derivatives XXXIV. On the progestational activity of 6-dehydro-16-methylene-17α-acetoxyprogesterone

Abstract By a modified Clauberg assay, 6-dehydro-17α-acetoxyprogesterone, 16-methylene-17α-acetoxyprogesterone, and 6-dehydro-16-methylene-17α-acetpxyprogesterone (DMAP) were found to be 1.5, 2.5, and 13 times, respectively, as active by oral administration as parenterally applied progesterone. A multiplicative effect of individual contributions of Δ 6 -double bond and 16-methylene group in DMAP was found. The correlation of structure and progestational activity is discused.