In-vivo characterization of angiogenesis in tumor-bearing rats using multiple scattering of ultrasound

There are significant differences in microvasculature density, tortuosity, and anisotropy of cancerous and benign tissue, which makes non-invasive methods to quantify these microvascular architectural properties highly relevant for applications like monitoring the response to anti-angiogenic treatments. We present a method to quantify these properties using ultrasound multiple scattering from contrast agent microbubbles injected into the vasculature.