Synthesis and Antiulcer, Anti-secretory Activity of Some New substituted 2-(Pyrimidinylsulfinyl) Benzamidazoles Derivatives

A series of all new substituted 2-(pyrimidinylsulfinyl) benzamidazoles derivatives synthesized from different starting material and evaluation against antiulcer and antisecretory activity as a inhibition of gastric H + /K + ATPase by induction of gastric ulcerations experimentally in male Wister rats according to the method. The newly synthesized compounds were characterized by IR and elemental analysis. All compounds were tested for antiulcer and antisecretory activities. The antiulcer activities of the compounds were assessed by Acetylsalicylic acid (ASA) method-induced gastric ulcer.