One-pot transformation of esters to analytically pure ketones: methodology and application in process development

A convenient, single-pot protocol for the transformation of esters into analytically pure ketones is described herein. This method circumvents the need for purification and affords near quantitative yields for all substrates investigated. As a test of its utility, the method is used to improve the yields of a process for preparing a pharmacologically relevant anti-HIV intermediate by nearly 10 fold.