Reduced systemic exposure and brain uptake of donepezil in rats with scopolamine-induced cognitive impairment

1. Donepezil (DPZ) is an acetylcholinesterase (AchE) inhibitor used in the mild to moderately severe Alzheimer’s disease. Among its major metabolites, 6-O-desmethyl DPZ (6-DDPZ), 5-O-desmet...