P21 Therapeutic effects of maternal melatonin on hemic/reperfusion-induced oxidative cerebral damage in neonatal rats

infection with C. pneumoniae and CMV and immune response in normal and preeclampsia complicated pregnancies. The first noteworthy finding of this work has shown that preeclampsia was associated with increased C. pneumonia genomic DNA loads compared with normal pregnancy controls and had higher anti-CMV IgG seropositivity than in women with normotensive interuterine growth restriction and normal pregnancy controls. Additionally, data synthesis revealed that IgG seropositivity of C. pneumonia and CMV was more prevalent among women with preeclampsia than normal pregnancy controls. The second finding of this work observed that early onset preeclampsia had increased Toll like receptor (TLR)-2 and -4 mRNA and protein expressions, elevated mRNA expressions of cryopyrin, NF-κB subunits and IL-1β, as well as increased TNF-α: IL-10 and IL-6: IL-10 ratios compared with normal pregnancy controls. Third, through a comprehensive review of published literatures and in combination of our study results, data suggested that TLR2 (Arg753Gln) and TLR4 co-segregating (Asp299Gly and Thr399Ile) gene polymorphisms seems in susceptibility to development of early onset preeclampsia. Our research findings indicated that TLRmicrobial with C. pneumonia and CMV interactions play an important role in maternal inflammatory syndroms in preeclampsia. This work may contribute for identification of novel anti-inflammatory targets for preeclampsia treatment, eventually leading to improved health care for both mom and fetus.