Effect of Li 1 upon the Mg 21 -Dependent Activation of Recombinant G ia1

, the G-protein that inhibits inositol mono-phosphatase. The addition of magnesium caused a re-versal of this inhibition (2). Thus, the G-protein hy-pothesis encompasses the inositol monophosphataseand the adenylate cyclase hypotheses, with G-proteinsbeing the common site for the antimanic and antide-pressive effects of Li