THE HISTOPATHOLOGICAL EXAMINATION OF MICE TISSUES AFTER THE TREATMENT WITH NEW SYNTHESIZED PROSTAMIDES WITH ANTIGLAUCOMA ACTION

Prostamides are nowadays considered as the most effective drugs used for the long term treatment of primary open angle glaucoma. New prostamides with potential antiglaucoma action were synthesized within the Department of Biosynthesis of Natural Products from the National Institute for Chemical and Pharmaceutical Research and Development, Bucharest. The current research is part of the preliminary toxicological studies and tries to assess the possible histopathological modifications of mice tissues after the treatment with new synthesized prostamides. Rezumat Prostamidele sau prostaglandin-etanolamidele sunt considerate la ora actuală cele mai eficiente medicamente antihipertensive oculare. In cadrul Departamentului de Sinteză Compusi Naturali de la Institutul Naţional de Cercetare si Dezvoltare ChimicoFarmaceutică, Bucuresti, au fost sintetizaţi noi compusi analogi structurali ai prostamidei F2α cu acţiune antihipertensivă oculară. Studiul face parte din testele preliminare toxicologice si isi propune stabilirea eventualelor modificări histopatologice ce pot să apară la soareci in urma tratamentului cu noile prostamide sintetizate.